Piperacillin: A specific, branded broad-spectrum antibiotic used to treat infections.

The CDC defines CRE as members of the Enterobacterales order resistant to at least one carbapenem antibiotic or producing a carbapenemase enzyme .
Regarding bacteria which are intrinsically not susceptible to imipenem (e.g., Proteus spp., Morganella spp., Providencia spp.), resistance to a minumum of one carbapenem other than imipenem is necessary .
CRE comprise a heterogenous group of pathogens with multiple potential mechanisms of resistance, broadly split into those that are carbapenemase-producing and those that aren’t carbapenemase-producing.
CRE that are not carbapenemase-producing may be the consequence of amplification of non-carbapenemase β-lactamase genes with concurrent outer membrane porin disruption .

Periodic assessment of hematopoietic function ought to be performed, especially with prolonged therapy, i.e., ≥ 21 days .
Cases of hemophagocytic lymphohistiocytosis have been reported in pediatric and adult patients treated with ZOSYN.
Signs and symptoms of HLH can include fever, rash, lymphadenopathy, hepatosplenomegaly and cytopenia.
If HLH is suspected, discontinue ZOSYN immediately and institute appropriate management.
No pharmacokinetic interactions have already been noted between piperacillin/tazobactam and vancomycin.
Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.
Only the concentration and diluents for amikacin or gentamicin with the dosages of ZOSYN in the above list have been established as compatible for co-administration via Y-site infusion.

Monotherapy Versus Combination Therapy For Multidrug-resistant Gram-negative Infections: Systematic Review And Meta-analysis

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Penicillin G interferes with the formation of cell wall mucopeptides during active multiplication, resulting in bactericidal activity against susceptible microorganisms.
Perform CBC counts before the initiation of therapy and at least weekly during therapy.

• There is limited information regarding Off-Label Guideline-Supported Usage of Piperacillin in adult patients.
• •Severe hypersensitivity reactions, including anaphylaxis, occur rarely.

Lidocaine is contraindicated in patients with a known history of hypersensitivity to local anesthetics of the amide type.
Appropriate cultures ought to be made for susceptibility testing before initiating therapy and therapy adjusted, if appropriate, once the results are known.